Regulatory T-cells and allogeneic hematopoietic stem cell transplantation
نویسندگان
چکیده
The article has summarized the available data about regulatory T cells, describing in-detail stages of their studying, development, classification, mechanisms immunosuppression in general terms and also context allogeneic hematopoietic stem cells transplantation. effect immunosuppressive agents on this cell population is considered. role pathogenesis both acute chronic graft-versus-host disease been revealed. possibilities clinical use (including modified cells) prevention treatment these complications are described detail.
منابع مشابه
Human regulatory T cells in allogeneic stem cell transplantation.
GVHD is still one of the major complications after allogeneic stem cell transplantation. Whereas murine data have clearly shown the beneficial effects of regulatory T cells (Tregs) on the prevention of GVHD, data from the human system are rare. Here, we present a comparative dynamic analysis of CD4(+)CD25(hi)CD127(lo/-) Tregs from patients with and without GVHD analyzing the whole genome profil...
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ژورنال
عنوان ژورنال: ????????????????
سال: 2022
ISSN: ['2713-2951']
DOI: https://doi.org/10.23873/2074-0506-2022-14-4-462-475